Journal
NEUROPSYCHOPHARMACOLOGY
Volume 36, Issue 1, Pages 98-113Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2010.121
Keywords
aversion; reward; inhibition; impulsivity; activation; punishment
Categories
Funding
- Human Frontiers Science Program [RGP0036/2009-C]
- Netherlands Organisation for Scientific Research (NWO)
- McKnight Foundation
- NARSAD
- NIH [R01MH087882-01]
- CRCNS
- Precursory for Embryonic Science and Technology, Takeda Foundation
- Nakayama Foundation
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH087882] Funding Source: NIH RePORTER
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Serotonin, like dopamine (DA), has long been implicated in adaptive behavior, including decision making and reinforcement learning. However, although the two neuromodulators are tightly related and have a similar degree of functional importance, compared with DA, we have a much less specific understanding about the mechanisms by which serotonin affects behavior. Here, we draw on recent work on computational models of dopaminergic function to suggest a framework by which many of the seemingly diverse functions associated with both DA and serotonin-comprising both affective and activational ones, as well as a number of other functions not overtly related to either-can be seen as consequences of a single root mechanism. Neuropsychopharmacology Reviews (2011) 36, 98-113; doi: 10.1038/npp.2010.121; published online 25 August 2010
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