Journal
NEUROPSYCHOPHARMACOLOGY
Volume 36, Issue 3, Pages 559-568Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2010.187
Keywords
cognition; inflammation; LTP; tau protein; transcranial magnetic stimulation
Categories
Funding
- Italian National Ministero dell'Universita e della Ricerca
- Italian National Ministero della Salute
- Fondazione TERCAS
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Cognitive dysfunction is of frequent observation in multiple sclerosis (MS). It is associated with gray matter pathology, brain atrophy, and altered connectivity, and recent evidence showed that acute inflammation can exacerbate mental deficits independently of the primary functional system involved. In this study, we measured cerebrospinal fluid (CSF) levels of amyloid-beta(1-42) and tau protein in MS and in clinically isolated syndrome patients, as both proteins have been associated with cognitive decline in Alzheimer's disease (AD). In AD, amyloid-beta(1-42) accumulates in the brain as insoluble extracellular plaques, possibly explaining why soluble amyloid-beta(1-42) is reduced in the CSF of these patients. In our sample of MS patients, amyloid-beta(1-42) levels were significantly lower in patients cognitively impaired (CI) and were inversely correlated with the number of Gadolinium-enhancing (Gd +) lesions at the magnetic resonance imaging (MRI). Positive correlations between amyloid-beta(1-42) levels and measures of attention and concentration were also found. Furthermore, abnormal neuroplasticity of the cerebral cortex, explored with theta burst stimulation (TBS), was observed in CI patients, and a positive correlation was found between amyloid-beta(1-42) CSF contents and the magnitude of long-term potentiation-like effects induced by TBS. No correlation was conversely found between tau protein concentrations and MRI findings, cognitive parameters, and TBS effects in these patients. Together, our results indicate that in MS, central inflammation is able to alter amyloid-beta metabolism by reducing its concentration in the CSF and leading to impairment of synaptic plasticity and cognitive function. Neuropsychopharmacology (2011) 36, 559-568; doi:10.1038/npp.2010.187; published online 13 October 2010
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