Journal
NEUROPSYCHOPHARMACOLOGY
Volume 34, Issue 1, Pages 173-186Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2008.174
Keywords
metabolomics; pharmacometabolomics; metabonomics; biomarkers; neurodegenerative; psychiatric diseases
Categories
Funding
- National Institutes of Health [R24 GM078233]
- National Institute of Neurological Disorders and Stroke
- National Institute of Aging [R01NS054008]
- SMRI
- NARSAD
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Metabolomics, the omics science of biochemistry, is a global approach to understanding regulation of metabolic pathways and metabolic networks of a biological system. Metabolomics complements data derived from genomics, transcriptomics, and proteomics to assist in providing a systems approach to the study of human health and disease. In this review we focus on applications of metabolomics for the study of diseases of the nervous system. We share concepts in metabolomics, tools used in metabolic profiling and early findings from the study of neuropsychiatric diseases, and drugs used to treat these diseases. Metabolomics emerges as another powerful tool in central nervous system research.
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