Journal
NEUROPSYCHOPHARMACOLOGY
Volume 33, Issue 12, Pages 2860-2869Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2008.22
Keywords
cortical inhibition; motor cortex; dorsolateral prefrontal cortex; electroencephalography; transcranial magnetic stimulation; GABAB receptor
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [MOP 62917]
- National Health and Medical Research Council (NHMRC)
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Lieber Young Investigator award
- Neuronetics Inc
Ask authors/readers for more resources
Several studies have demonstrated that cortical inhibition (CI) can be recorded by paired transcranial magnetic stimulation (TMS) of the motor cortex and recorded by surface electromyography (EMG). However, recording CI from other cortical regions that are more closely associated with the pathophysiology of some neurological and psychiatric disorders (eg, dorsolateral prefrontal cortex (DLPFC) in schizophrenia) was previously unattainable. This study, therefore, was designed to investigate whether CI could be measured directly from the motor cortex and DLPFC by combining TMS with electroencephalography ( EEG). Long-interval CI ( LICI) is a TMS paradigm that was used to index CI in the motor cortex and DLPFC in healthy subjects. In the motor cortex, LICI resulted in significant suppression (32.8 +/- 30.5%) of mean cortical evoked activity on EEG, which was strongly correlated with LICI recorded by EMG. In the DLPFC, LICI resulted in significant suppression (30.1 +/- 26.9%) of mean cortical evoked activity and also correlated with LICI in the motor cortex. These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurological and psychiatric disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available