Journal
NEUROPSYCHOLOGY REVIEW
Volume 23, Issue 3, Pages 234-256Publisher
SPRINGER
DOI: 10.1007/s11065-013-9235-4
Keywords
Alzheimer's disease; Limb apraxia; Pantomime; Imitation; Tool use; Transitive gesture; Intransitive gesture
Categories
Funding
- ANR (Agence Nationale pour la Recherche
- Project Demences et Utilisation d'Outils/Dementia and Tool Use [ANR 2011 MALZ 006 03]
- Region Pays de la Loire (Project Outils et Vie Quotidienne/Tool Use and Daily Life Activities) [2012-09689 OVQ]
- LABEX CORTEX of Universite de Lyon (Francois Osiurak), within the program Investissements d'Avenir [ANR-11-IDEX-0007]
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Apraxia is one of the cognitive deficits that characterizes Alzheimer's disease. Despite its prevalence and relevance to diagnosing Alzheimer's disease, this topic has received little attention and is without comprehensive review. The review herein is aimed to fill this gap by first presenting an overview of the impairment caused in different clinical situations: pantomime of tool use, single tool use, real tool use, mechanical problem solving, function and manipulation knowledge tasks, and symbolic/meaningless gestures. On the basis of these results, we then propose alternative interpretations regarding the nature of the underlying mechanisms impaired by the disease. Also presented are principal methodological issues precluding firm conclusions from being drawn.
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