Journal
NEUROPSYCHOLOGY REVIEW
Volume 20, Issue 2, Pages 209-225Publisher
SPRINGER
DOI: 10.1007/s11065-010-9129-7
Keywords
Diffusion tensor imaging; White matter; Cognition; Psychiatric and neurological diseases
Categories
Funding
- NIAAA [AA012388, AA010723, AA017168, AA017923]
- NIA [AG019717]
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As Norman Geschwind asserted in 1965, syndromes resulting from white matter lesions could produce deficits in higher-order functions and disconnexion or the interruption of connection between gray matter regions could be as disruptive as trauma to those regions per se. The advent of in vivo diffusion tensor imaging, which allows quantitative characterization of white matter fiber integrity in health and disease, has served to strengthen Geschwind's proposal. Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.
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