Journal
NEUROPSYCHOLOGY REVIEW
Volume 20, Issue 3, Pages 280-289Publisher
SPRINGER
DOI: 10.1007/s11065-010-9141-y
Keywords
Cerebellum; Alcohol; Alcoholism; Executive function; Structural imaging; Functional imaging
Categories
Funding
- U.S. National Institute on Alcohol Abuse and Alcoholism [AA010723, AA017168, AA017923]
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [U01AA017923, R01AA010723, K05AA017168, R37AA010723] Funding Source: NIH RePORTER
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Neuropathological, neuropsychological, and neuroimaging studies of human alcoholism provide evidence for degradation of frontal, pontine, thalamic, and cerebellar brain sites and disturbed associated functions. Current studies using neuroimaging combined with examination of executive functions, traditionally considered the sole purview of the frontal lobes, have identified a role for the cerebellum serving as a compensatory processing adjunct to enable normal performance on challenging tasks tapping executive functions. This overview proposes that disruption of an executive frontocerebellar network is a major contributor to characteristic behaviors of alcoholism that, on the one hand, enable alcohol use disorders, and on the other hand, lead to compensation for dysfunctions in alcoholism traditionally considered frontally-based.
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