Journal
NEUROPSYCHOLOGY
Volume 24, Issue 1, Pages 121-129Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0016981
Keywords
schizophrenia; cingulum bundle; white matter; orbital frontal cortex; gray matter
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [K05MH070047] Funding Source: NIH RePORTER
- NIMH NIH HHS [K05 MH070047, K05 MH070047-06] Funding Source: Medline
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The authors examined the relationship between neuropsychological performance and MRI of the orbital frontal cortex (OFC) and diffusion tensor imaging (DTI) of the cingulum bundle (CB) within groups of patients with schizophrenia and healthy subjects. The authors analyzed data from Subjects, who had participated in prior MRI, DTI, and neuropsychological studies (Nakamura et it., 2008 Nestor et A, 2008). In comparison to healthy subjects, patients showed the expected reductions across CB fractional anisotropy (white matter) and OFC gray matter volume as well as lower neuropsychological scores. In addition, in comparison to healthy subjects, patients showed a very different pattern of functional-anatomical correlates. For patients, CB white matter but not OFC gray matter correlated with various aspects of intelligence. including general abilities and working memory. For controls, OFC gray matter but not CB white matter correlated with scores on tests of intelligence and decision making. These results point to the potentially important role of CB white matter in the neuropsychological disturbance in schizophrenia.
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