Memory loss resulting from fornix and septal damage: Impaired supra-span recall but preserved recognition over a 24-hour delay

Despite increasing evidence that the fornix is important for memory. uncertainty remains about the exact nature Of Subsequent impairments arising from damage to this tract. This uncertainty is often created by pathology in additional brain structures. The present Study involved it Young man, DN, who had almost complete bilateral loss of the rostral columns of the fornix and much of the surrounding septum in the left hemisphere following the surgical removal of a cavernous angioma. Quantitative MRI analyses of structure size. normalized to intracranial Volume. showed no difference in any of the additional brain regions measured, apart from those areas removed to expose the tumor. DN showed it marked, stable anterograde memory impairment that was still present 4 years postsurgery. In contrast, DN performed within normal levels on most tests of recognition memory. This sparing wits most striking when given a 24-hr delay between study and test of the Warrington Recognition Memory Test. This recall/recognition dissociation provides further evidence for neuroanatomical divisions within recognition memory processes.