Journal
NEUROPSYCHOLOGY
Volume 22, Issue 6, Pages 776-786Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0013404
Keywords
HIV; substance use disorders; basal ganglia; nondeclarative memory; neuropsychology
Categories
Funding
- HHS [F32 DA018522, R01 DA12829]
Ask authors/readers for more resources
Human immunodeficiency virus (HIV) and drugs of abuse affect common neural systems underlying procedural memory, including the striatum. The authors compared performance of 48 HIV seropositive (HIV+) and 48 HIV seronegative (HIV-) participants with history of cocaine and/or heroin dependence across multiple Trial Blocks of three procedural learning (PL) tasks: Rotary Pursuit (RP), Mirror Star Tracing (MST), and Weather Prediction (WP). Groups were well matched on demographic, psychiatric. and substance use parameters, and all participants were verified abstinent from drugs. Mixed model analyses of variance revealed that the individuals in the HIV+ group performed more poorly across all tasks, with a significant main effect of HIV serostatus observed oil the Mirror Star Tracing and a trend toward significance obtained for the Rotary Pursuit task. No significant differences were observed oil the Weather Prediction task. Both groups demonstrated significant improvements in performance across all three procedural learning tasks. It is important to note that no significant Serostatus X Trial Block interactions were observed oil any task. Thus. the individuals in the HIV+ group tended to perform worse than those in the HIV- group across all trial blocks of procedural learning tasks with motor demands, but showed no differences in their rate of improvement across all tasks. These findings are consistent with HIV--associated deficits in complex motor skills, but not in procedural learning.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available