Journal
NEUROPSYCHOLOGIA
Volume 47, Issue 13, Pages 2828-2834Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2009.06.011
Keywords
Stop-signal task; Thalamocortical circuits; Inferior frontal gyrus
Funding
- Norman Collison Foundation
- Charles Wolfson Charitable Trust
- Medtronic
- MRC [G0701698] Funding Source: UKRI
- Medical Research Council [G0701698] Funding Source: researchfish
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We measured reaction times during a stop-signal task while patients with Parkinson's disease were on and off unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN). While reaction times to a go stimulus improved, there was no change in reaction times to the stop stimulus (SSRTs). However, changes in SSRTs induced by DBS were highly dependent on baseline SSRTs (measured off stimulation), with the greatest improvements being achieved by those with particularly slow reaction times. We therefore selected only those patients whose baseline SSRTs were within the limits of a control sample (N=10). In this group, SSRTs became slower when DBS was on. This finding suggests a role for the STN in response inhibition, which can be interrupted by DBS, observable only when more general improvements in Parkinson's function are minimised. We also compared the effects of unilateral left and right sided stimulation. We found a greater increase in SSRTs after DES of the left STN. (C) 2009 Elsevier Ltd. All rights reserved.
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