Journal
NEUROPHARMACOLOGY
Volume 145, Issue -, Pages 177-198Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2018.09.032
Keywords
Neurotrauma; Traumatic brain injury; Cell therapy; Stem cells; Drug-based therapy; Clinical trials
Categories
Funding
- Department of Defense [W81XWH-16-2-0008]
- AUB-MPP grant Dual Neurotherapeutic Effects of Docosahexaenoic Acid (DHA) and Arachidonic Acid (AA) with Neonatal Neural Stem Cell transplantation Post-Traumatic Brain Injury
- University Research Board (URB)
- Kamal A. Shair Research Fund (KS)
- Farouk Jabre Biomedical Research Grants (FJ)
- Collaborative Research Stimulus (CRS) grants at AUB
- Lebanese National Council for Scientific Research (LNCSR)
- Miami Project to Cure Paralysis
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Traumatic brain injury (TBI) has been recognized as one of the major public health issues that leads to devastating neurological disability. As a consequence of primary and secondary injury phases, neuronal loss following brain trauma leads to pathophysiological alterations on the molecular and cellular levels that severely impact the neuropsycho-behavioral and motor outcomes. Thus, to mitigate the neuropathological sequelae post-TBI such as cerebral edema, inflammation and neural degeneration, several neurotherapeutic options have been investigated including drug intervention, stem cell use and combinational therapies. These treatments aim to ameliorate cellular degeneration, motor decline, cognitive and behavioral deficits. Recently, the use of neural stem cells (NSCs) coupled with selective drug therapy has emerged as an altemative treatment option for neural regeneration and behavioral rehabilitation post-neural injury. Given their neuroprotective abilities, NSC-based neurotherapy has been widely investigated and well-reported in numerous disease models, notably in trauma studies. In this review, we will elaborate on current updates in cell replacement therapy in the area of neurotrauma. In addition, we will discuss novel combination drug therapy treatments that have been investigated in conjunction with stem cells to overcome the limitations associated with stem cell transplantation. Understanding the regenerative capacities of stem cell and drug combination therapy will help improve functional recovery and brain repair post-TBI. This article is part of the Special Issue entitled Novel Treatments for Traumatic Brain Injury.
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