Journal
NEUROPHARMACOLOGY
Volume 140, Issue -, Pages 260-274Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2018.08.008
Keywords
Ouabain; Wnt; BDNF; Hippocampus; Dendritic branching; Reference memory
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2011/22844-0, 2016/07427-8]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq, Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES) - University of Sao Paulo [2011.1.9333.1.3]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Universidade de Sao Paulo
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Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NF kappa B and CREB. These transcription factors play a key role in the regulation of BDNF and WNT-beta-catenin signaling cascades, which are involved in neuroprotection and memory regulation. This study investigated the effects of OUA (10 nM) in the modulation of the principal signaling pathways involved in morphological plasticity and memory formation in the hippocampus of adult rats. The results show intrahippocampal injection of OUA 10 nM to activate the Wnt/beta-Catenin signaling pathway and to increase CREB/BDNF and NF kappa B levels. These effects contribute to important changes in the cellular micro environment, resulting in enhanced levels of dendritic branching in hippocampal neurons, in association with an improvement in spatial reference memory and the inhibition of long-term memory extinction.
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