Journal
NEUROPHARMACOLOGY
Volume 76, Issue -, Pages 269-275Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2013.06.016
Keywords
Transgenerationa; Epigenetic; Drugs of abuse; Alcohol; Nicotine; Marijuana; Opioids; Cocaine
Categories
Funding
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA033641, R03DA034886, K02DA018678, R01DA025674] Funding Source: NIH RePORTER
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It is clear that both genetic and environmental factors contribute to drug addiction. Recent evidence indicating trans-generational influences of drug abuse highlight potential epigenetic factors as well. Specifically, mounting evidence suggests that parental ingestion of abused drugs influence the physiology and behavior of future generations even in the absence of prenatal exposure. The goal of this review is to describe the trans-generational consequences of preconception exposure to drugs of abuse for five major classes of drugs: alcohol, nicotine, marijuana, opioids, and cocaine. The potential epigenetic mechanisms underlying the transmission of these phenotypes across generations also are detailed. (C) 2013 Elsevier Ltd. All rights reserved.
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