Journal
NEUROPHARMACOLOGY
Volume 86, Issue -, Pages 1-8Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2014.06.021
Keywords
Stress; D-serine; NMDA receptor; Serine racemase; Prepulse inhibition; Object recognition task; Cognition
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Programa de Pesquisas para o SUS (FAPERJ/MS-Decit/CNPq)
- Instituto Nacional de Ciencia e Tecnologia de Biologia Estrutural e Bioimagem
- FAPERJ
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Increasing evidence indicates that acute stress disrupts cognitive functions mediated by glutamate-NMDA receptors, although the mechanisms are not fully understood. Here we investigated whether D-serine and glycine, the endogenous co-agonists of the NMDA receptor, are regulated by acute stress. We studied the biochemical and behavioral effects of acute restraint stress in C57BL/6 mice. Acute restraint stress decreased D-serine levels in the prefrontal cortex and glycine levels in the hippocampus. Behaviorally, acute stress impaired memory consolidation in the object recognition task and prepulse inhibition of the startle response. Importantly, D-serine administration (1 g/kg, i.p.) prevented both stress-induced impairments. Taken together, our results show for the first time an interplay between stress and D-serine and warrant further research on the role of D-serine in stress-related disorders. (C) 2014 Elsevier Ltd. All rights reserved.
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