Journal
NEUROPHARMACOLOGY
Volume 76, Issue -, Pages 603-609Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2013.04.054
Keywords
BDNF; proBDNF; Neuronal morphology; Cytoskeleton; Rho GTPases; Signalling
Categories
Funding
- NIA NIH HHS [R01 AG025970] Funding Source: Medline
- NICHD NIH HHS [P01 HD023315] Funding Source: Medline
- NIMH NIH HHS [R01 MH086651] Funding Source: Medline
- NINDS NIH HHS [R56 NS021072, R01 NS021072] Funding Source: Medline
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Both mature BDNF and its precursor, proBDNF, play a crucial role in shaping neurons and contributing to the structural basis for neuronal connectivity. They do so in a largely opposing manner, and through differential engagement with their receptors. In this review, we will summarise the evidence that BDNF modulates neural circuit formation in vivo both within the central and peripheral nervous systems, through the control of neuronal morphology. The underlying intracellular mechanisms that translate BDNF signalling into changes of neuronal cell shape will be described. In addition, the signalling pathways that act either locally at the site of BDNF action, or over long distances to influence gene transcription will be discussed. These mechanisms begin to explain the diversity of actions that BDNF carries out on neuronal morphology. (C) 2013 Elsevier Ltd. All rights reserved.
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