Journal
NEUROPHARMACOLOGY
Volume 85, Issue -, Pages 367-374Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2014.04.019
Keywords
Prelimbic cortex; Opioid receptors; Autonomic; Restraint stress
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/00249-9, 2012/09300-4, 2012/17626-7]
- CAPES [PNPD0176087]
- CNPq [474477/2013-4]
- FAEPA
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/09300-4] Funding Source: FAPESP
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The prelimbic cortex (PL) is involved in the control of behavioral and autonomic responses to stress. The present study aimed to investigate whether opioid neurotransmission in the PL modulates autonomic responses evoked by restraint stress (RS). Bilateral microinjection of 0.03, 0.3 and 3 nmol/100 nL of the nonselective opioid antagonist naloxone into the PL reduced pressure and tachycardiac responses evoked by RS. However, no effects were observed after its injection at doses of 0.003 and 30 nmol/100 nL, thus resulting in an inverted U-shaped dose-inhibition curve. Similar to naloxone, the selective mu-opioid antagonist CTAP, and the selective mu-opioid antagonist nor-BNI, also reduced MAP and HR increases induced by RS when injected into the PL, whereas treatment with the selective delta-opioid antagonist naltrindole did not affect the pressor and tachycardiac response caused by RS. Blockade of opioid neurotransmission in the PL did not affect the fall in tail temperature and increase in body temperature induced by RS. The present results confirm the involvement of PL opioid neurotransmission in the modulation of cardiovascular responses evoked during the exposure to an aversive situation, and suggest that responses observed after the blockade of local opioid receptors is due to alterations in PL neuronal activity. Furthermore, these results suggest that a distinct circuitry is involved in modulation of the sympathetic output to different vascular territories. (C) 2014 Elsevier Ltd. All rights reserved.
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