Journal
NEUROPHARMACOLOGY
Volume 76, Issue -, Pages 581-591Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2013.04.034
Keywords
Nicotine; Withdrawal; Cognition; Attention; Working memory; Smoking cessation
Categories
Funding
- National Institute on Drug Abuse [R01 DA026849, R01 DA030819, P50 CA143187]
- National Center for Research Resources [UL1 RR024134]
- NIH [T32 GM008076]
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Nicotine withdrawal is associated with deficits in neurocognitive function including sustained attention, working memory, and response inhibition. Several convergent lines of evidence suggest that these deficits may represent a core dependence phenotype and a target for treatment development efforts. A better understanding of the mechanisms underlying withdrawal-related cognitive deficits may lead to imprpve nicotine dependence treatment. We begin with an overview of the neurocognitive effects of withdrawal in rodent and huinan models, followed by discussion of the neurobehavioral mechanisms that are thought to underlie these effects. We then review individual differences in withdrawal-related neurocognitive effects including genetics, gender, and psychiatric comorbidity. We conclude with a discussion of the implications of this research for developing improved therapies, both pharmacotherapy and behavioral treatments, that target cognitive symptoms of nicotine withdrawal. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'. (C) 2013 Elsevier Ltd. All rights reserved.
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