Journal
NEUROPHARMACOLOGY
Volume 63, Issue 1, Pages 46-56Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2011.10.008
Keywords
Peptide YY (PYY); Glucagon like peptide-1 (GLP-1); Oxyntomodulin; Cholecystokinin; Ghrelin; Obesity
Categories
Funding
- MRC
- BBSRC
- NIHR
- Integrative Mammalian Biology (IMB) Capacity Building Award [FP7-HEALTH-2009-241592 EuroCHIP]
- Medical Research Council
- EFSD Paul Langerhans
- BBSRC [BB/I00842X/1] Funding Source: UKRI
- MRC [G1000474] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I00842X/1] Funding Source: researchfish
- Medical Research Council [G1000474] Funding Source: researchfish
- National Institute for Health Research [CDF-2011-04-006, ACF-2006-21-011] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [CDF-2011-04-006] Funding Source: National Institutes of Health Research (NIHR)
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Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity. This article is part of a Special Issue entitled 'Central Control Food Intake' Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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