Journal
NEUROPHARMACOLOGY
Volume 62, Issue 1, Pages 135-143Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2011.07.037
Keywords
Zebrafish; Anxiety; Novelty-based paradigms; Pharmacological and genetic manipulations; Bioinformatics; Omics-based tools
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Funding
- Tulane University
- Tulane Neurophenotyping Platform, Tulane University
- Newcomb Fellows grant
- NIH/NIDA SOAR [R03 DA030900-01]
- NATIONAL INSTITUTE ON DRUG ABUSE [R03DA030900] Funding Source: NIH RePORTER
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Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral research. Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states. Here, we evaluate established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish. Experimental approaches to modeling anxiety in zebrafish include novelty-based paradigms, pharmacological and genetic manipulations, as well as innovative video-tracking, 3D-reconstructions, bioinformatics-based searchable databases and omics-based tools. Complementing traditional rodent models of anxiety, we provide a conceptual framework for the wider application of zebrafish and other aquatic models in anxiety research. This article is part of a Special Issue entitled 'Anxiety and Depression'. (C) 2011 Elsevier Ltd. All rights reserved.
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