Journal
NEUROPHARMACOLOGY
Volume 62, Issue 2, Pages 598-606Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2011.03.016
Keywords
PTSD; TBI; Head injury; Trauma; Concussion; Loss of consciousness; Military; Brain injury; Meta-analysis; fMRI; Review; Amygdala; Insula; Prefrontal cortex; Dorsolateral frontal cortex; Middle frontal cortex; Comorbid; Combat; Brain imaging
Categories
Funding
- Veterans Administration
- VA MIRECC
- UCSD CESAMH
- VA Merit
- VA Clinical Science Research and Development Service
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Posttraumatic Stress Disorder (PTSD) and mild traumatic brain injury (mTBI) often occur together. Parsing out the unique and overlapping effects of these conditions on the brain, can inform the selection of appropriate treatments. Although recent studies indicate that warfighters in Operations Enduring and Iraqi Freedom are at a high risk for PTSD and mTBI, there is a dearth of research directly comparing their neural correlates. In this paper, we briefly discuss these conditions and supply two meta-analyses of the relevant functional magnetic resonance imaging studies conducted to date. By looking at the overlap in these analyses, we suggest that the middle frontal gyrus may be an appropriate area for future investigations aimed at disentangling PTSD and mTBI. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'. Published by Elsevier Ltd.
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