Journal
NEUROPHARMACOLOGY
Volume 58, Issue 1, Pages 179-184Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2009.06.042
Keywords
Self-administration; Reinstatement; Addiction; Abstinence; Orexin; Cocaine
Categories
Funding
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA017289, P50DA015369, R37DA006214] Funding Source: NIH RePORTER
- NIDA NIH HHS [R01 DA017289-06, R37-DA06214, R01 DA017289, P50-DA015369, R37 DA006214-21, R01-DA017289, R37 DA006214, P50 DA015369-070007, P50 DA015369] Funding Source: Medline
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Orexin/hypocretin signaling at the orexin 1 receptor (OX1R) has recently been implicated in addiction and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Male Sprague-Dawley rats self-administered cocaine in 2-h sessions for 10 days, followed by extinction training or extended abstinence in the home cage. The OX1R antagonist SB-334867 (SB; 10, 20, or 30 mg/kg, i.p.) was administered prior to re-exposure to the cocaine self-administration environment. We found that pretreatment with SB significantly attenuated cocaine-seeking when rats were placed back into the self-administration environment following either 1 day or 2 weeks of abstinence (no extinction), or following extinction of cocaine-seeking in an alternative environment (distinct from the training environment). These results indicate that orexin signaling at OX1R is critical for conditioned cocaine-seeking elicited by a drug-associated context, following either extinction or abstinence. (C) 2009 Elsevier Ltd. All rights reserved.
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