Journal
NEUROPHARMACOLOGY
Volume 56, Issue -, Pages 169-173Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2008.07.011
Keywords
Glutamate; Sensitization; Drug-seeking; Ventral tegmental area; Nucleus accumbens
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Funding
- NIDA NIH HHS [P50 DA015369-07, P50 DA015369, DA12513, R37 DA003906, DA015369, DA03906, R01 DA003906, R01 DA015851, R01 DA012513, R37 DA003906-26, R01 DA012513-10, DA015851] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA003906, R37DA003906, R01DA015851, P50DA015369, R01DA012513] Funding Source: NIH RePORTER
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Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locornotor sensitization and drUg-seeking. While glUtarnate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction. (c) 2008 Elsevier Ltd. All rights reserved.
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