Journal
NEUROPEPTIDES
Volume 42, Issue 5-6, Pages 557-567Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.npep.2008.08.004
Keywords
Alzheimer's diseased; Beta-amyloid protein; S14G-Humanin; Behavioral deficits; Neuroinflammation; Apoptosis
Categories
Funding
- Natural science Foundation of Shaanxi Province of China [2006C215]
- National Natural Science Foundation of China [30570641]
Ask authors/readers for more resources
Cerebral amyloid-beta protein (A beta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to Suppress neuronal death induced by AD-related insults in vitro. Furthermore, limited in vivo studies show that HNG can ameliorate memory impairment induced by intracerebroventricular injection of anti-cholinergic drugs or A beta 25-35. However, the mechanism underlying the in vivo effect remains unclear. In this study, we sought to determine the effects of HNG on neuroinflammatory responses and apoptosis associated with behavioral deficits induced by A beta 25-35 in vivo. Our results indicate that intracerebroventricular injection of aggregated A beta 25-35 induced impairment of learning and memory, markedly elevated numbers of reactive astrocytes, activated microglia, and apoptotic cells, as well as remarkable increased levels of IL-6 and TNF alpha. Moreover, intraperitoneal HNG treatment ameliorated behavioral deficits, and reduced neuroinflammatory responses and apoptotic cells in the brain. Cumulatively, these finding demonstrate for the first time that HNG may have the potential for attenuating A beta-induced cognitive deficits by reducing inflammatory responses and apoptosis in vivo, which may add to the novel evidence for anti-inflammatory and antiapoptosis properties of HNG in AD treatment. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available