Journal
NEURON
Volume 84, Issue 2, Pages 470-485Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2014.08.051
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Funding
- National Institute of Health [NS34994, MH54671, NS074015]
- National Science Foundation [SBE 0542013]
- Human Frontier Science Program
- James S. McDonnell Foundation
- G. Harold and Leila Y. Mathers Charitable Foundation
- European Molecular Biology Organization and Fundancion La Caixa
- EU-FP7-ERC-Starting grant [337075]
- Momentum program of the Hungarian Academy of Sciences
- Swiss National Science Foundation
- European Research Council (ERC) [337075] Funding Source: European Research Council (ERC)
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Precisely how rhythms support neuronal communication remains obscure. We investigated interregional coordination of gamma oscillations using high-density electrophysiological recordings in the rat hippocampus and entorhinal cortex. We found that 30-80 Hz gamma dominated CA1 local field potentials (LFPs) on the descending phase of CA1 theta waves during navigation, with 60-120 Hz gamma at the theta peak. These signals corresponded to CA3 and entorhinal input, respectively. Above 50 Hz, interregional phase-synchronization of principal cell spikes occurred mostly for LFPs in the axonal target domain. CA1 pyramidal cells were phase-locked mainly to fast gamma (>100 Hz) LFP patterns restricted to CA1, which were strongest at the theta trough. While theta phase coordination of spiking across entorhinal-hippocampal regions depended on memory demands, LFP gamma patterns below 100 Hz in the hippocampus were consistently layer specific and largely reflected afferent activity. Gamma synchronization as a mechanism for interregional communication thus rapidly loses efficacy at higher frequencies.
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