Journal
NEURON
Volume 82, Issue 6, Pages 1289-1298Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2014.04.040
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Funding
- National Health and Medical Research Council (NHMRC) [1029975, 1064174, 1043044]
- Australian Research Council (ARC) Discovery project grant
- NHMRC Principal Research Fellowship
- ARC Australian Professorial Fellowship
- University of Queensland Masters of Neuroscience scholarship
- Australian Postgraduate Award
- National Health and Medical Research Council of Australia [1064174] Funding Source: NHMRC
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Bilateral integration of sensory and associative brain processing is achieved by precise connections between homologous regions in the two hemispheres via the corpus callosum. These connections form postnatally, and unilateral deprivation of sensory or spontaneous cortical activity during a critical period severely disrupts callosal wiring. However, little is known about how this early activity affects precise circuit formation. Here, using in utero electroporation of reporter genes, optogenetic constructs, and direct disruption of activity in callosal neurons combined with whisker ablations, we show that balanced interhemispheric activity, and not simply intact cortical activity in either hemisphere, is required for functional callosal targeting. Moreover, bilateral ablation of whiskers in symmetric or asymmetric configurations shows that spatially symmetric interhemispheric activity is required for appropriate callosal targeting. Our findings reveal a principle governing axon targeting, where spatially balanced activity between regions is required to establish their appropriate connectivity.
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