Journal
NEURON
Volume 82, Issue 4, Pages 723-725Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2014.05.002
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- NIMH NIH HHS [U19 MH082441] Funding Source: Medline
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In this issue of Neuron, Stachniak et al. (2014) determine that the chemogenetic silencer hM4Di-DREADD suppresses presynaptic glutamate release, and by generating an axon-targeted hM4Di variant they demonstrate that it can be used to locally silence synaptic transmission in neural circuits.
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