Journal
NEURON
Volume 82, Issue 3, Pages 522-536Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2014.01.018
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Funding
- NIH [NS14627, NS78326, DA29204]
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The original formulation of Gate Control Theory (GCT) proposed that the perception of pain produced by spinal cord signaling to the brain depends on a balance of activity generated in large (nonnociceptive)-and small (nociceptive)-diameter primary afferent fibers. The theory proposed that activation of the large-diameter afferent closes the gate by engaging a superficial dorsal horn interneuron that inhibits the firing of projection neurons. Activation of the nociceptors opens the gate through concomitant excitation of projection neurons and inhibition of the inhibitory interneurons. Sixty years after publication of the GCT, we are faced with an ever-growing list of morphologically and neurochemically distinct spinal cord interneurons. The present Review highlights the complexity of superficial dorsal horn circuitry and addresses the question whether the premises outlined in GCT still have relevance today. By examining the dorsal horn circuits that underlie the transmission of pain and itch messages, we also address the extent to which labeled lines can be incorporated into a contemporary view of GCT.
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