Journal
NEURON
Volume 83, Issue 4, Pages 771-787Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2014.08.005
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Funding
- National Institutes of Health
- Lupe Murchison Foundation
- Ted Nash Longlife Foundation
- Consortium for Frontotemporal Dementia Research
- Alexander von Humboldt Stiftung
- Brightfocus Foundation
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Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adult brain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.
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