Journal
NEURON
Volume 77, Issue 1, Pages 35-42Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2012.10.035
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Funding
- HFSP
- BBSRC
- EC
- Royal Society
- MICINN
- Michael Foster Studentship
- Felix Scholarship
- BBSRC [BB/H002383/2] Funding Source: UKRI
- MRC [G0400571] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H002383/2] Funding Source: researchfish
- Medical Research Council [G0001354, G1000183B, G0400571, G0001354B] Funding Source: researchfish
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A central tenet of most theories of synaptic modification during cortical development is that correlated activity drives plasticity in synaptically connected neurons. Unexpectedly, however, using sensory-evoked activity patterns recorded from the developing mouse cortex in vivo, the synaptic learning rule that we uncover here relies solely on the presynaptic neuron. A burst of three presynaptic spikes followed, within a restricted time window, by a single presynaptic spike induces robust long-term depression (LTD) at developing layer 4 to layer 2/3 synapses. This presynaptic spike pattern-dependent LTD (p-LTD) can be induced by individual presynaptic layer 4 cells, requires presynaptic NMDA receptors and calcineurin, and is expressed presynaptically. However, in contrast to spike timing-dependent LTD, p-LTD is independent of postsynaptic and astroglial signaling. This spike pattern-dependent learning rule complements timing-based rules and is likely to play a role in the pruning of synaptic input during cortical development.
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