Journal
NEURON
Volume 80, Issue 1, Pages 51-63Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2013.07.022
Keywords
-
Categories
Funding
- Japan Society for the Promotion of Science (JSPS)
- Robert Leet and Clara Guthrie Patterson Trust Postdoctoral Fellowship
- Bank of America
- Trustee
- Special Postdoctoral Researchers Program of RIKEN
- RIKEN Brain Science Institute
- Japan Science and Technology Agency
- National Eye Institute (NEI) [R01-EY11001]
- Gatsby Charitable Foundation through the Gatsby Initiative in Brain Circuitry at Columbia University
- [1806772]
Ask authors/readers for more resources
What causes critical periods (CPs) to open? For the best-studied case, ocular dominance plasticity in primary visual cortex in response to monocular deprivation (MD), the maturation of inhibition is necessary and sufficient. How does inhibition open the CP? We present a theory: the transition from pre-CP to CP plasticity arises because inhibition preferentially suppresses responses to spontaneous relative to visually driven input activity, switching learning cues from internal to external sources. This differs from previous proposals in (1) arguing that the CP can open without changes in plasticity mechanisms when activity patterns become more sensitive to sensory experience through circuit development, and (2) explaining not simply a transition from no plasticity to plasticity, but a change in outcome of MD-induced plasticity from pre-CP to CP. More broadly, hierarchical organization of sensory-motor pathways may develop through a cascade of CPs induced as circuit maturation progresses from lower to higher cortical areas.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available