Journal
NEURON
Volume 80, Issue 2, Pages 250-253Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2013.09.031
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Funding
- NIA NIH HHS [R01 AG022560, RF1 AG022560] Funding Source: Medline
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In this issue of Neuron, Suh et al. (2013) describe two rare ADAM10 prodomain mutations that cause late-onset Alzheimer's disease by impairing prodomain chaperone function, attenuating a-secretase activity, and reducing adult hippocampal neurogenesis. These results support both ADAM10 as a therapeutic target and the amyloid hypothesis of Alzheimer's disease.
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