Counting Gephyrins, One at a Time: A Nanoscale View on the Inhibitory Postsynapse

Gephyrin is the key scaffolding molecule organizing the postsynaptic density at inhibitory synapses. Utilizing localization microscopy, Specht et al. (2013) report in this issue of Neuron on the quantitative assessment of gephyrin clusters and associated glycine receptors and GABA(A) receptors.