Journal
NEURON
Volume 76, Issue 1, Pages 160-174Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2012.08.037
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Funding
- NIMH Conte Center [P50 MH60398]
- NIDA [P01 DA021633]
- Office of Naval Research (ONR) [N00014-09-1-0598, N00014-12-1-0366]
- Pritzker Neuropsychiatric Disorders Research Consortium Fund LLC
- Hope for Depression Research Foundation, NCRR [UL1RR024986]
- Rachel Upjohn Clinical Scholars Award
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In this review, we propose a broader view of the role of the fibroblast growth factor (FGF) family in modulating brain function. We suggest that some of the FGF ligands together with the FGF receptors are altered in individuals with affective disorder and modulate emotionality in animal models. Thus, we propose that members of the FGF family may be genetic predisposing factors for anxiety, depression, or substance abuse; that they play a key organizing role during early development but continue to play a central role in neuroplasticity in adulthood; and that they work not only over extended time frames, but also via rapid signaling mechanisms, allowing them to exert an on-line influence on behavior. Therefore, the FGF family appears to be a prototype of switch genes that are endowed with organizational and modulatory properties across the lifespan, and that may represent molecular candidates as biomarkers and treatment targets for affective and addictive disorders.
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