Journal
NEURON
Volume 73, Issue 6, Pages 1173-1183Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2012.02.015
Keywords
-
Categories
Funding
- National Center of Competences in Research
- Swiss National Science Foundation
- NRSA [F32 MH880102]
- PILM (MIT)
- National Institutes of Health
- Howard Hughes Medical Institute
- Defense Advanced Research Projects Agency
- Gatsby Charitable Foundation
- Woo Foundation
- Snyder Foundation
- Yu Foundation
- Wiegers Family Fund
Ask authors/readers for more resources
Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA(A) receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available