4.8 Article

Dopamine Enhances Model-Based over Model-Free Choice Behavior

Journal

NEURON
Volume 75, Issue 3, Pages 418-424

Publisher

CELL PRESS
DOI: 10.1016/j.neuron.2012.03.042

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Funding

  1. Wellcome Trust [078865/Z/05/Z, 091593/Z/10/Z]
  2. Max Planck Society

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Decision making is often considered to arise out of contributions from a model-free habitual system and a model-based goal-directed system. Here, we investigated the effect of a dopamine manipulation on the degree to which either system contributes to instrumental behavior in a two-stage Markov decision task, which has been shown to discriminate model-free from model-based control. We found increased dopamine levels promote model-based over model-free choice.

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