Journal
NEURON
Volume 73, Issue 6, Pages 1159-1172Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2012.01.027
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Funding
- Centre National de la Recherche Scientifique
- Fondation Fyssen
- Fondation pour la Recherche Medicale
- Federation pour la Recherche sur le Cerveau
- Agence Nationale de la Recherche (Neuroscience and Blanc)
- European Commision [LSHM-CT-2007-037765]
- Fondation pour la Recherche Medicate
- Swedish Research Council
- Grants-in-Aid for Scientific Research [22500362] Funding Source: KAKEN
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Interneurons are critical for neuronal circuit function, but how their dendritic morphologies and membrane properties influence information flow within neuronal circuits is largely unknown. We studied the spatiotemporal profile of synaptic integration and short-term plasticity in dendrites of mature cerebellar stellate cells by combining two-photon guided electrical stimulation, glutamate uncaging, electron microscopy, and modeling. Synaptic activation within thin (0.4 mu m) dendrites produced somatic responses that became smaller and slower with increasing distance from the soma, sublinear subthreshold input-output relationships, and a somatodendritic gradient of short-term plasticity. Unlike most studies showing that neurons employ active dendritic mechanisms, we found that passive cable properties of thin dendrites determine the sublinear integration and plasticity gradient, which both result from large dendritic depolarizations that reduce synaptic driving force. These integrative properties allow stellate cells to act as spatiotemporal filters of synaptic input patterns, thereby biasing their output in favor of sparse presynaptic activity.
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