Journal
NEURON
Volume 72, Issue 2, Pages 385-396Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2011.09.013
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Funding
- MRC [G0501632]
- Royal Society
- Experimental Psychology Society
- Overseas Research Scholarship (UK)
- Nakajima Foundation (Japan)
- Medical Research Council [G0501632] Funding Source: researchfish
- MRC [G0501632] Funding Source: UKRI
- Grants-in-Aid for Scientific Research [22530794] Funding Source: KAKEN
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Traditional neurological models of language were based on a single neural pathway (the dorsal pathway underpinned by the arcuate fasciculus). Contemporary neuroscience indicates that anterior temporal regions and the ventral language pathway also make a significant contribution, yet there is no computationally-implemented model of the dual pathway, nor any synthesis of normal and aphasic behavior. The Lichtheim 2 model was implemented by developing a new variety of computational model which reproduces and explains normal and patient data but also incorporates neuroanatomical information into its architecture. By bridging the mind-brain gap in this way, the resultant neurocomputational model provides a unique opportunity to explore the relationship between lesion location and behavioral deficits, and to provide a platform for simulating functional neuroimaging data.
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