Journal
NEURON
Volume 71, Issue 3, Pages 512-528Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2011.05.043
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Funding
- Deutsche Forschungsgemeinschaft [SFB TR3]
- Nationales Genomforschungsnetzwerk NGFNplus EmiNet
- EPICURE
- ERANET Neuron 'EpiNet'
- Ministry for Innovation, Research, Science, Research, and Technology NRW
- University of Bonn Medical Center
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Hippocampal granule cells are important relay stations that transfer information from the entorhinal cortex into the hippocampus proper. This process is critically determined by the integrative properties of granule cell dendrites. However, their small diameter has so far hampered efforts to examine their properties directly. Using a combination of dual somatodendritic patch-clamp recordings and multiphoton glutamate uncaging, we now show that the integrative properties of granule cell dendrites differ substantially from other principal neurons. Due to a very strong dendritic voltage attenuation, the impact of individual synapses on granule cell output is low. At the same time, integration is linearized by voltage-dependent boosting mechanisms, only weakly affected by input synchrony, and independent of input location. These experiments establish that dentate granule cell dendritic properties are optimized for linear integration and strong attenuation of synaptic input from the entorhinal cortex, which may contribute to the sparse activity of granule cells in vivo.
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