Journal
NEURON
Volume 71, Issue 1, Pages 61-75Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2011.05.029
Keywords
-
Categories
Funding
- Jean and George Brumley Jr. Endowment
- Ruth K. Broad Foundation
- Sontag Foundation
- David & Lucile Packard Foundation
- March of Dimes [5-FY09-34]
- N.I.H. [1 DP2 OD004453-01]
- MRC [G0900424] Funding Source: UKRI
- Medical Research Council [G0900424] Funding Source: researchfish
Ask authors/readers for more resources
The rodent subventricular/subependymal zone (SVZ/SEZ) houses neural stem cells (NSCs) that generate olfactory bulb interneurons. It is unclear how the SVZ environment sustains neuronal production into adulthood. We discovered that the adapter molecule Ankyrin-3 (Ank3) is specifically upregulated in ventricular progenitors destined to become ependymal cells, but not in NSCs, and is required for SVZ niche assembly through progenitor lateral adhesion. Furthermore, we found that Ank3 expression is controlled by Foxj1, a transcriptional regulator of multicilia formation, and genetic deletion of this pathway led to complete loss of SVZ niche structure. Interestingly, radial glia continued to transition into postnatal NSCs without this niche. However, inducible deletion of Foxj1-Ank3 from mature SVZ ependyma resulted in dramatic depletion of neurogenesis. Targeting a pathway regulating ependymal organization/assembly and showing its requirement for new neuron production, our results have important implications for environmental control of adult neurogenesis and harvesting NSCs for replacement therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available