Journal
NEURON
Volume 70, Issue 1, Pages 43-50Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2011.02.044
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Funding
- Dutch Organization for Medical Sciences
- Life Sciences
- Erasmus University
- Senter
- Prinses Beatrix Fonds
- SENSOPAC [C7]
- CEREBNET of the European Community
- United States Public Health Service [MH51106, NS36715]
- Howard Hughes Medical Institute
- Grants-in-Aid for Scientific Research [22300122] Funding Source: KAKEN
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Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or alpha CamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different cerebellar coordination tasks (adaptation of the vestibulo-ocular reflex, eyeblink conditioning, and locomotion learning on the Erasmus Ladder), we show that there is no motor learning impairment in these mutant mice that lack PF-PC LTD. These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning.
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