Journal
NEURON
Volume 69, Issue 1, Pages 6-8Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2010.12.030
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Funding
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NIDA NIH HHS [R01 DA006241, T32 DA007242, R37 DA007242, R01 DA013997, R01 DA007242-21, R01 DA007242, R01 DA006241-21, R21 DA029244, R01 DA002615, R56 DA002615, R01 DA002615-31] Funding Source: Medline
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Heterodimerization of G protein-coupled receptors has become increasingly recognized as a valuable mechanism to increase receptor diversity. Heterodimers have been observed in the opioid receptor family, but one of the most intriguing is that formed between mu-opioid and delta-opioid receptors. In this issue of Neuron, He et al. present evidence further implicating these heterodimers in morphine tolerance.
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