Journal
NEURON
Volume 65, Issue 5, Pages 585-596Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2010.02.014
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIMH NIH HHS [P50 MH086404] Funding Source: Medline
Ask authors/readers for more resources
The cognitive symptoms of schizophrenia are largely resistant to current treatment and are thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused on prefrontal cortex because of its demonstrated importance for executive function and working memory-key components of the deficit. The role of striatal-cortical circuitry and therefore the striatum itself has received much less attention. Here we review longstanding evidence that the striatum and its cortical connections are critical for complex cognition and discuss emerging evidence of the striatum's potential involvement in cognitive symptoms. Finally, we suggest how mouse models might test ideas about the contribution of early striatal dysfunction to the cognitive symptoms of schizophrenia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available