Journal
NEURON
Volume 67, Issue 4, Pages 543-554Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2010.07.021
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Funding
- NIDA NIH HHS [R01 DA030241, R01 DA030241-02, R01 DA011723-08, R01 DA011723] Funding Source: Medline
- NIMH NIH HHS [R01 MH085496, R01 MH085496-06] Funding Source: Medline
- NINDS NIH HHS [T32 NS043124-10, T32 NS043124] Funding Source: Medline
- Autism Speaks [AS1947] Funding Source: Medline
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The pervasiveness of decision-making in every area of human endeavor highlights the importance of understanding choice mechanisms and their detailed relationship to underlying neurobiological function. This review surveys the recent and productive application of game-theoretic probes (economic games) to mental disorders. Such games typically possess concrete concepts of optimal play, thus providing quantitative ways to track when subjects' choices match or deviate from optimal. This feature equips economic games with natural classes of control signals that should guide learning and choice in the agents that play them. These signals and their underlying physical correlates in the brain are now being used to generate objective biomarkers that may prove useful for exposing and understanding the neurogenetic basis of normal and pathological human cognition. Thus, game-theoretic probes represent some of the first steps toward producing computationally principled, objective measures of cognitive function and dysfunction useful for the diagnosis, treatment, and understanding of mental disorders.
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