Journal
NEURON
Volume 65, Issue 3, Pages 298-308Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2009.12.022
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Funding
- National Institute of Mental Health [5R01-MH076932, F32-NS059195]
- National Alliance for Research on Schizophrenia and Depression
- Alfred P. Sloan Foundation
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High-resolution functional MRI (hr-fMRI) affords unique leverage on the functional properties of human medial temporal lobe (MTL) substructures. We review initial hr-fMRI efforts to delineate (1) encoding and retrieval processes within the hippocampal circuit, (2) hippocampal subfield contributions to pattern separation and pattern completion, and (3) the representational capabilities of distinct MTL subregions. Extant data reveal functional heterogeneity within human MTL and highlight the promise of hr-fMRI for bridging human, animal, and computational approaches to understanding MTL function.
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