Journal
NEURON
Volume 67, Issue 2, Pages 171-173Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2010.07.011
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Funding
- NIA NIH HHS [P01 AG014930-04S1, P01 AG014930] Funding Source: Medline
- NINDS NIH HHS [R01 NS039258, R01 NS039258-01] Funding Source: Medline
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Mutant huntingtin proteolysis mediated by various proteases plays a key role in Huntington's disease (HD) pathogenesis. In this issue of Neuron, Miller et al. have identified 11 proteases, including matrix metalloproteinases (MMPs), that when inhibited reduce huntingtin proteolysis and produce beneficial therapeutic effects. These findings provide new insights into huntingtin proteolysis and its potential as a therapeutic target.
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