Journal
NEURON
Volume 61, Issue 4, Pages 502-510Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2009.01.031
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Funding
- Medical Research Council (UK)
- Wellcome Trust
- Eli Lilly
- Pfizer
- GlaxoSmithKline
- Medical Research Council [G0001354B, G0001354] Funding Source: researchfish
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In rare instances, patients with Parkinson's disease (PD) may become addicted to their own medication or develop behavioral addictions such as pathological gambling. This is surprising because PD patients typically have a very low incidence of drug abuse and display a personality type that is the polar opposite of the addictive personality. These rare addictive syndromes, which appear to result from excessive dopaminergic medication use, illustrate the link between dopamine, personality, and addiction. We describe the clinical phenomena and attempt to relate them to current models of learning and addiction. We conclude that persistently elevated dopaminergic stimulation promotes the development and maintenance of addictive behaviors.
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