Journal
NEURON
Volume 61, Issue 1, Pages 57-70Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2008.11.012
Keywords
-
Categories
Funding
- NIH [T32GM007377-31, T32DC008072, R01DC5991]
- Sandier Program
- Department of Psychiatry and Behavioral Sciences
- UC Davis School of Medicine Health Sciences Award
- NSF [0317136]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0317136] Funding Source: National Science Foundation
Ask authors/readers for more resources
Prolonged stimulation leads to specific and stable changes in an animal's behavior. In interneurons, this plasticity requires spatial and temporal control of neuronal protein synthesis. Whether such translational control occurs in sensory neurons is not known. Adaptation of the AWC olfactory sensory neurons of C. elegans requires the cGMP-dependent protein kinase EGL-4. Here, we show that the RNA-binding PUF protein FBF-1 is required in the adult AWC for adaptation. In the odor-adapted animal, it increases translation via binding to the egl-4 3'UTR. Further, the PUF protein may localize translation near the sensory cilia and cell body. Although the RNA-binding PUF proteins have been shown to promote plasticity in development by temporally and spatially repressing translation, this work reveals that in the adult nervous system, they can work in a different way to promote experience-dependent plasticity by activating translation in response to environmental stimulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available