Journal
NEURON
Volume 64, Issue 2, Pages 267-280Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2009.08.037
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Funding
- National Institutes of Health [NS034994, MH54671]
- National Science Foundation [SBE 0542013]
- J.D. McDonnell Foundation
- Uehara Memorial Foundation
- Astellas Foundation
- Japan Society
- Robert Leet & Clara Guthrie Patterson Trust
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Theta oscillations are believed to play an important role in the coordination of neuronal firing in the entorhinal (EC)-hippocampal system but the underlying mechanisms are not known. We simultaneously recorded from neurons in multiple regions of the EC-ippocampal loop and examined their temporal relationships. Theta-coordinated synchronous spiking of EC neuronal populations predicted the timing of current sinks in target layers in the hippocampus. However, the temporal delays between population activities in successive anatomical stages were longer (typically by a half theta cycle) than expected from axon conduction velocities and passive synaptic integration of feed-forward excitatory inputs. We hypothesize that the temporal windows set by the theta cycles allow for local circuit interactions and thus a considerable degree of computational independence in subdivisions of the EC-hippocampal loop.
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