Journal
NEURON
Volume 63, Issue 4, Pages 497-507Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2009.07.027
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Funding
- National Institutes of Health (NIH) [MH061976]
- Singleton Fellowship
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During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences corresponding to recent spatial experience. Such replay co-occurs with ripple events: short-lasting (similar to 50-120 ms), high-frequency (similar to 200 Hz) oscillations that are associated with increased hippocampal-cortical communication. In previous studies, rats exploring small environments showed replay anchored to the rat's current location and compressed in time into a single ripple event. Here, we show, using a neural decoding approach, that firing sequences corresponding to long runs through a large environment are replayed with high fidelity and that such replay can begin at remote locations on the track. Extended replay proceeds at a characteristic virtual speed of similar to 8 m/s and remains coherent across trains of ripple events. These results suggest that extended replay is composed of chains of shorter subsequences, which may reflect a strategy for the storage and flexible expression of memories of prolonged experience.
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